Power-Frequency Fields and Cancer (J. Moulder, v8, 17-Nov-93) Notice: This FAQ sheet may b
Power-Frequency Fields and Cancer (J. Moulder, v8, 17-Nov-93)
Notice: This FAQ sheet may be redistributed as long at remains correctly
attributed. If it is edited or condensed prior to redistribution, please add
a note to that effect.
v8: (17-Nov-93): Discussion of newly published European studies of powerlines
and cancer expanded. Meta-analysis sections updated to include the new
studies and more cautionary notes. Section of bioeffects expanded, and
reference to the EMF-melatonin-cancer hypothesis added. Several Gauss to
Tesla conversion errors corrected.
1) Why is there a concern about power lines and cancer?
Most of the concern about power lines and cancer stems from epidemiological
studies of people living near distribution and transmission lines, and
epidemiological studies of people working in "electrical occupations". Some
of these epidemiological studies appear to show a relationship between
exposure to power-frequency fields and the incidence of cancer. Laboratory
studies have shown little evidence of a link between power-frequency fields
2) What's the difference between the electromagnetic [EM] energy associated
with power lines and other forms of EM energy such as microwaves or x-rays?
X-rays, ultraviolet (UV) light, visible light, infrared light, microwaves
(MW), radiowaves (RF), and magnetic fields from electrical power systems are
all parts of the EM spectrum. The parts of the EM spectrum are
characterized by their frequency or wavelength. The frequency and wavelength
are related, and as the frequency rises the wavelength gets shorter. The
frequency is the rate at which the EM field changes direction and is usually
given in Hertz (Hz), where one Hz is one cycle per second.
Power-frequency fields in the US vary 60 times per second, so they are 60 Hz
fields, and have a wavelength of 3000 miles (5000 km). Power in most of the
rest of the world is at 50 Hz. Broadcast AM radio has a frequency of around
one million Hz and a wavelength of around 1000 ft (300 m). Microwave ovens
have a frequency of about 2 billion Hz, and a wavelength of about 5 inches
(12 cm). X-rays and UV light have frequencies of millions of billions of Hz,
and wavelengths of less than a thousandth of an inch (10 nm or less).
3) What differences are there in the biological effects of these different
portions of the EM spectrum?
The interaction of biological material with an EM source depends on the
frequency of the source. We usually talk about the EM spectrum as though it
produced waves of energy. This is not strictly correct, because sometimes EM
energy acts like particles rather than waves; this is particularly true at
high frequencies. This double nature of the EM spectrum is referred to as
"wave-particle duality". The particle nature of EM energy is important
because it is the energy per particle (or photons, as these particles are
called) that determines what biological effects EM energy will have.
At the very high frequencies characteristic of UV light and X-rays, EM
particles (photons) have sufficient energy to break chemical bonds. This
breaking of bonds is termed ionization, and this portion of the EM spectrum
is termed ionizing radiation. At lower frequencies, such as those
characteristic of visible light, radiowaves, and microwaves, the photons
don't carry enough energy to break chemical bonds; but they do carry enough
energy to cause molecules to vibrate, causing heating. These are called
thermal effects, and this portion of the EM spectrum is termed the thermal,
non-ionizing portion. At frequencies below those used in commercial
broadcast radio (such as the 50/60 Hz frequencies generated in the production
and distribution of electricity), the photons have insufficient energy to
cause heating, and this portion of the EM spectrum is termed the non-thermal,
4) What is difference between EM radiation and EM fields?
In general, EM sources produce both radiant energy (radiation) and non-
radiant energy (fields). Radiated energy exists apart from its source,
travels away from the source, and continues to exist even if the source is
turned off. Non-radiant energy is not projected away into space, and it
ceases to exist when the energy source is turned off. When a person or
object is more than several wavelengths from an EM source, a condition called
far-field, the radiation component of the EM source dominates. In the far-
field the electrical and magnetic components are closely related. When a
person or object is less than one wavelength from an EM source, a condition
called near-field, the field effect dominates, and the electrical and
magnetic components are unrelated.
For ionizing frequencies where the wavelengths are less than a thousandth of
an inch (less than 10 nm), human exposure is entirely in the far-field, and
only the radiation from the EM source is relevant to possible health effects.
For MW and RF, where the wavelengths are in inches to a few thousand feet (a
few cm to a km), human exposure can be in both the near- and the far-field,
so that both field and radiation effects are relevant. For power-frequency
fields, where the wavelength is thousands of miles (thousands of km), human
exposure is always in the near-field, and only the field component is
relevant to possible health effects.
5) How do ionizing EM sources cause biological effects?
Ionizing EM radiation carries sufficient energy per photon to break chemical
bonds. In particular, ionizing radiation is capable of breaking bonds in the
genetic material of the cell, the DNA. Severe damage to DNA can kill cells,
resulting in tissue damage or death. Lesser damage to DNA can result in
permanent changes in the cells which may lead to cancer. If these changes
occur in reproductive cells, they can lead to inherited changes, a phenomena
called mutation. All of the known hazards from exposure to the ionizing
portion of the EM spectrum are the result of the breaking of chemical bonds
in DNA. For frequencies below that of UV light, DNA damage does not occur
because the photons do not have enough energy to break chemical bonds. Well-
accepted safety standards exist to prevent significant damage to the genetic
material of persons exposed to ionizing EM radiation.
6) How do the thermal non-ionizing EM sources cause biological effects?
Visible light, MW, and RF can cause molecules to vibrate, causing heating.
This molecular heating can kill cells. If enough cells are killed, burns and
other forms of long-term, and possibly permanent tissue damage can occur.
Cells which are not killed by heating gradually return to normal after the
heating ceases; permanent non-lethal cellular damage is not known to occur.
All of the known hazards from exposure to the thermal non-ionizing portion of
the EM spectrum are the result of heating. For frequencies below about the
middle of the AM broadcast spectrum, this heating does not occur because the
photons do not have enough energy to cause molecular vibrations.
The molecular vibration caused by MW is how and why a MW oven works -
exposure of the food to the microwaves causes water molecules to vibrate and
get hot. MW and RF penetrate and heat best when the size of the object is
close to the wavelength. For the 2450 MHz (2.45 billion Hz) used in
microwave ovens the wavelength is 5 inches (12 cm), a good match for most of
what we cook.
7) How do the power-frequency EM fields cause biological effects?
The electrical and magnetic fields associated with power-frequency fields
cannot break bonds or cause molecular heating because the energy per photon
is too low. Thus the known mechanisms through which ionizing radiation, MWs
and RFs effect biological material have no relevance for power-frequency
The electrical fields associated with the power-frequency fields exist
whenever voltage is present, and regardless of whether current is flowing.
These electrical fields have very little ability to penetrate buildings or
even skin. The magnetic fields associated with power-frequency fields exist
only when current is flowing. These magnetic fields are difficult to shield,
and easily penetrate buildings and people. Because power-frequency
electrical fields do not penetrate, any biological effects from routine
exposure to power-frequency fields must be due to the magnetic component of
Exposure of people to power-frequency magnetic fields results in the
induction of electrical currents in the body. These currents are similar to
naturally-occurring currents. It requires a power-frequency magnetic field
in excess of 5 Gauss (500 microT, see Q8 for typical exposures) to induce
electrical currents of a magnitude similar to those that occur naturally in
the body. Electrical currents that are above those that occur naturally in
the body can cause noticeable effects, including direct nerve stimulation.
Well-accepted safety standards exist to protect persons from exposure to
power-frequency fields that would induce such currents (see Q16 for safety
8) What sort of power-frequency magnetic fields are common in residences and
In the US magnetic fields are commonly measured in Gauss (G) or milliGauss
(mG), where 1,000 mG = 1G. In the rest of the world, they are measured in
Tesla (T), were 10,000 Gauss equals 1 Tesla (1 Gauss = 100 microT; 1 microT =
10 milliGauss). Power-frequency fields are measured with a calibrated gauss
meter. Measurements must be done in multiple locations over a substantial
period of time because there are large variations in fields over space and
Within the right-of-way (ROW) of a high voltage transmission line, fields can
approach 100 mG (0.1 G, 10 microT). At the edge of a high-voltage
transmission ROW, the field will be 1-10 mG (0.1-1.0 microT). Ten meters
from a 12 kV distribution line will be fields will be 2-10 mG (0.2-1.0
microT). Actual fields depend on voltage, design and current.
Fields within residences vary from over 1000 mG (100 microT) a few inches
(cm) from certain appliances to less than 0.2 mG (0.02 microT) in the center
of some rooms. Appliances that have the highest fields are those with high
currents (e.g., toasters, electric blankets) or high-speed electric motors
(e.g., vacuum cleaners, electric clocks, blenders, power tools). Appliance
fields decrease very rapidly with distance. See ref. 24 for further details.
Occupational exposures in excess of 100 mGauss (10 microT) have been reported
(e.g., in arc welders and electrical cable splicers). In "electrical"
occupations mean exposures range from 5 to 40 mG (0.5 to 4 microT). See ref.
24 for further details.
9) What is known about the relationship between powerline corridors and
Some studies have shown that children (but not adults) living near certain
types of powerlines (high current distribution lines and transmission lines)
have higher than average rates of leukemia, lymphomas and brain cancers (Refs
1-3, 38). The correlation is not strong, and none of the studies have shown
dose-response relationships. When power-frequency fields are actually
measured, the correlation vanishes. Several other studies have shown no
correlations between residence near power lines and cancer risk (Refs 4-6,
10) How big is the "cancer risk" associated with living next to a powerline?
The excess cancer found in epidemiological studies is usually quantified in a
number called the relative risk (RR). This is the risk of an "exposed"
person getting cancer divided by the risk of an "unexposed" person getting
cancer. Since no one is unexposed to power-frequency fields, the comparison
is actually "high exposure" versus "low exposure". A RR of 1.0 means no
effect, a RR of less the 1.0 means a decreased risk in exposed groups, and a
RR of greater than one means an increased risk in exposed groups. Relative
risks are generally given with 95% confidence intervals. These 95%
confidence intervals are almost never adjusted for multiple comparisons even
when multiple types of cancer and multiple indices of exposure are studied.
An overview of the epidemiology requires that studies be combined using a
technique known as "meta-analysis". Meta-analysis is not easy to do, since
the epidemiological studies of residential exposure use a wide variety of
methods for assessing "exposure". Meta-analysis also gets out-of-date
rapidly in this field. The following RRs (called summary RRs in meta-
analysis) for the residential exposure studies are adapted from refs. 7 and
39 by inclusion of the new European studies (see Q13). The confidence
intervals should be viewed as measures of the diversity of the data, rather
than as strict tests of the statistical significance of the data.
childhood leukemia: 1.5 (0.7 - 3.0) 8 studies
childhood brain cancer: 1.9 (0.9 - 2.9) 6 studies
childhood lymphoma: 2.5 (0.3 - 40) 2 studies
all childhood cancer: 1.5 (0.9 - 3.0) 5 studies
adult leukemia: 1.1 (0.8-1.6) 3 studies
adult brain cancer: 0.7 (0.4 - 1.3) 1 study
all adult cancer: 1.1 (0.9-1.3) 3 studies
As a base-line for comparison, the age-adjusted cancer incidence rate for
adults in the United States is 3 per 1,000 per year for all cancer (that is,
0.3% of the population gets cancer in a given year),and 1 per 10,000 per year
for leukemia (ref. 26).
11) What is known about the relationship between "electrical occupations"
and cancer rates?
Several studies have shown that people who work in electrical occupations
have higher than average leukemia, lymphoma, and brain cancer rates (refs 8-
10). Most of the cautions listed for the residential studies apply here
also: many negative studies, weak correlations, no dose-response
relationships. Additionally, these studies are mostly based on job titles,
not on measured exposures.
Meta-analysis of the occupational studies is even more difficult than the
residential studies. First, a variety of epidemiological techniques are
used, and studies using different techniques should not really be combined.
Second, a wide range of definitions of "electrical occupations" are used, and
very few studies actually measured exposure. The following RRs (see Q10) for
the occupational exposure studies are adapted from refs 7 and 40. Again, the
confidence intervals should be viewed as measures diversity rather than as
tests of the statistical significance.
leukemia: 1.15 (1.0-1.3) 28 studies
brain: 1.15 (1.0-1.4) 19 studies
lymphoma: 1.2 (0.9-1.5) 6 studies
all cancer: 1.0 (0.9-1.1) 8 studies
The above relative risks do not take into account the recent European studies
(Q13). Adding these new studies raises the summary RR for leukemia to about
1.2, and lowers the summary RRs for brain cancer and lymphomas to essentially
one. Another new study of cancer in the electrical power industry (ref 30)
shows no significant elevation of leukemia, brain cancer or lymphoma risks.
12) What do laboratory studies tell us about power-frequency fields and
Carcinogens, agents that cause cancer, are generally of two types: genotoxins
and promoters. Genotoxic agents (often called initiators) directly damage
the genetic material of cells. Genotoxins usually effect all types of cells,
and may cause many different types of cancer. Genotoxins generally do not
have thresholds for their effect; in other words, as the dose of the
genotoxin is lowered the risk gets smaller, but it never goes away. A
promoter (often called an epigenetic agent) is something that increases the
cancer risk in animals already exposed to a genotoxic carcinogen. Promoters
usually effect only certain types of cells, and may cause only certain types
of cancer. Promoters generally have thresholds for their effect; in other
words, as the dose of the promoter is lowered a level is reached in which
there is no risk.
Power-frequency fields show none of the classic signs of being genotoxins -
they do not cause DNA damage or chromosome breaks, and they are not mutagenic
(refs 11-15 and see ref 31 for a comprehensive review). No studies have
shown that animals exposed to power-frequency fields have increased cancer
There are agents (for example, promoters) that influence the development of
cancer without directly damaging the genetic material. It has been suggested
that power-frequency EMFs could promote cancer (refs 17 & 18). Most
promotion studies of power-frequency fields have been negative (refs 14, 19-
21); but recently there was a positive report of promotion of breast cancer
in rats (ref 31).
There are other biological effects that might be related to cancer. There
are substances (called mitogens) that cause non-growing normal cells to start
growing. Some mitogens appear to be carcinogens. There have been numerous
studies of the effects of power-frequency fields on cell growth
(proliferation) and tumor growth (progression). Studies of effects on
proliferation and progression have had very mixed results: 75% show no effect
on growth, while the rest are about equally mixed between studies showing
increased growth and studies showing decreased growth (refs 11, 12, 15, 20-
22, 33). With one possible exception (ref 33) there have been no reported
effects on proliferation or progression for fields below 2000 mGauss (200
Suppression of the immune system in animals and humans is associated with
increased rates of certain types of cancer, particularly lymphomas (refs 34
and 35). Immune suppression has not been associated with excess leukemia and
brain cancer. Some studies have shown that power frequency fields can have
effects on cells of the immune system (41), but no studies have shown the
type or magnitude of immunesuppression that is associated with increased
It has also been suggested that power-frequency EM fields might suppress the
production of the hormone melatonin, and that melatonin has "cancer-
preventive" activity (42, 43). This is highly speculative. There have been
some reports that EM fields effect melatonin production, but studies using
power-frequency magnetic fields have not shown reproducible effects. In
addition, while there is evidence that melatonin has "cancer-preventive"
activity against breast cancer in rats, there is no evidence that melatonin
effects other types of cancer, or that it has any effect on breast cancer in
While the laboratory evidence does not suggest a link between power-frequency
magnetic fields and cancer, numerous studies have reported that these fields
do have "bioeffects", particularly at high field strength (refs 16, 17, 41).
Power-frequency fields intense enough to induce electrical currents in excess
of those that occur naturally (above 5 G, 500 microT see Q7) have shown
reproducible effects, including effects on humans (ref 16). Below about 2 G
(200 microT) there are few published (and replicated) reports of bioeffects,
although there are unreplicated reports of effects for fields as low as about
200 mG (20 microT). Even among the scientists who believe that there may be a
connection between power-frequency fields and cancer, there is no consensus
as to mechanisms which would connect these "bioeffects" with cancer causation
(refs 16, 18).
13) What about the new "Swedish" study showing a link between power lines
There are new residential and occupational studies from Sweden, Denmark (36,
38), Finland (37) and the Netherlands (44). The Swedish studies are
available only as translations of the unpublished preliminary reports. The
published studies are considerably more cautious in there interpretations of
the data than were the unpublished preliminary reports and the earlier press
- Fleychting & Ahlbom [Magnetic fields and cancer in people residing near
Swedish high voltage powerlines]. A case-control study of everyone who
lived within 300 meters of high-voltage powerlines between '60 and '85. For
children all types of tumors were analyzed, for adults only leukemia and
brain tumors were studied. "Exposure" was assessed by spot measurements,
calculated retrospective assessments, and distance from powerlines. No
increased overall cancer risk was found for either children or adults. An
increased risk for leukemia (but not other cancers) was found in children for
*calculated* fields at the time of diagnosis. It is not clear if or how the
retrospective fields calculations take into account sources other the
transmission lines. No significantly elevated cancer risks were found for
measured fields or proximity to transmission lines.
- Verkasalo et al (ref 37). Study design similar to Fleychting & Ahlbom
(above). Cohort study of cancer in children in Finland living within 500 m
of high-voltage lines. Only calculated retrospective fields were used to
define exposure. The calculated fields are based only on lines of 110 kV and
above and do not take into account fields from other sources such as
distribution lines, household wiring or appliances. Both average fields and
cumulative fields (microT - years) were used as exposure metrics. For all
cancers the RR was 1.5 (0.7 - 2.7) for average exposure above 0.20 microT (2
mG), and 1.4 (0.8 - 2.3) for cumulative exposure above 0.50 microT-years. A
significant excess risk of brain cancer way found in boys, the excess was due
entirely to one exposed boy who developed three independent brain tumors. No
significantly increased risks were found for brain tumors in girls or for
leukemia, lymphomas or "other" tumors in either sex.
- Olsen and Nielson (ref 38). Case-control study based on all childhood
leukemia, brain tumors and lymphomas diagnosed in Denmark between '68 and
'86. "Exposure" was assessed on the basis of calculated fields over the
period from conception to diagnosis. No overall increase in cancer risk was
found when 0.25 microT (2.5 mG) was used as the cut-point to define exposure
(as specified in the study design). After the data were analyzed, it was
found that the risk for all childhood cancer was significantly elevated if
0.40 microT (4 mG) was used as the cut-point. For the 0.40 microT cut-point
the RR for all cancer was 5.6 (1.2 - 20). No significant increased risk was
found for leukemia or brain cancer for any cut-point. A significant increase
in lymphoma risk was found for the 0.10 microT cut-point but not for higher
- Guenel et al (ref 36). Case-control study based on all cancer in actively
employed Danes between '70 and '87 who were 20-64 years old in 1970. Each
occupation-industry combination was coded on the basis of supposed 50-Hz
magnetic field exposure. No significant increases in risk were seen for
breast cancer, malignant lymphomas or brain tumors. Leukemia incidence was
elevated among men in the highest "exposure" category; women in similar
exposure categories showed no excess risk. For men in the highest "exposure"
category the RR for leukemia was 1.6 (1.2 - 2.2).
-Floderus et al [Occupational exposure to EM fields in relation to leukemia
and brain tumors]. Case-control study of leukemia and brain tumors of men,
20-64 years of age in '80. "Exposure" calculations were based on the job
held longest during the 10-year period prior to diagnosis. Many measurements
were taken using a person whose job was most similar to that of the person in
the study. About two-thirds of the subjects in the study could be assessed in
this manner. A significantly elevated risk was found for leukemia, but not
for brain cancer.
14) How do scientists evaluate all the confusing and contradictory
laboratory and epidemiological studies of power-frequency magnetic fields and
There are certain widely accepted criteria that are weighed when assessing
such groups of studies. These are often called the "Hill criteria" (ref.
- First, what is the *strength of the association* between exposure and risk -
- is there a clear risk associated with exposure? A strong association is
one with a RR (see Q9) of 5 or more. Tobacco smoking, for example, shows a
RR for lung cancer 10-30 times that of non-smokers.
Most of the positive power-frequency studies have RRs of less than two. The
leukemia studies as a group have RRs of about 1.2, while the brain cancer
studies as a group have RRs of about 1.5. This is only a weak association.
- Second, are there many *consistent studies* indicating the same risk -- do
most studies show about the same risk for the same disease? Using the same
example, essentially all studies of smoking and cancer showed an increased
risk for lung and head-and-neck cancers.
Many power-frequency studies show statistically significant risks for some
types of cancers and some types of exposures, but many do not. Even the
positive studies are inconsistent with each other. For example, while a new
Swedish study shows an increased risk for childhood leukemia for one measure
of exposure, it contradicts prior studies that showed a risk for brain
cancers, and a parallel Danish study shows a risk for childhood lymphomas,
but not for leukemia. Many of the studies are internally inconsistent. For
example, where the Swedish study shows an increased risk for childhood
leukemia, it shows no overall increase in childhood cancer, implying that the
rates of other types of cancer are decreased. In summary, few studies show
the same positive result, so that the consistency is weak.
- Third, is there evidence for a *dose-response relationship* -- does risk
increase when the exposure increases? Again, the more a person smokes, the
higher the risk of lung cancer.
No published power-frequency exposure study has shown a dose-response
relationship between measured fields and cancer rates, or between distances
from transmission lines and cancer rates. The lack of a relationship between
exposure and increased cancer risk is a major reason why many scientists are
skeptical about the significance of the epidemiology.
- Fourth, is there *laboratory evidence* suggesting that there is a risk
associated with such exposure? Epidemiological associations are greatly
strengthened when there is laboratory evidence for a risk. When the US
Surgeon General first stated that smoking caused lung cancer, the laboratory
evidence was ambiguous. It was known that cigarette smoke and tobacco
contained carcinogens, but no one had been able to make lab animals get
cancer by smoking (mostly because it's hard to convince animals to smoke).
Power-frequency fields show little evidence of the type effects on cells,
tissues or animals that point towards their being a cause of cancer, or to
their contributing to cancer.
-Fifth, are there *plausible biological mechanisms* that suggest that there
should be a risk? When it is understood how something causes disease, it is
much easier to interpret ambiguous epidemiology. With smoking, for example,
the fact that there were known cancer-causing agents in tobacco made it very
easy to believe the epidemiology.
From what is known of power-frequency fields and their effects on biological
systems there is no reason to even suspect that they pose a risk to people at
the exposure levels associated with the generation and distribution of
- Overall the evidence for a connection between power frequency fields and
cancer is weak, because of the weakness and inconsistencies in the
epidemiological studies, combined with the lack of a dose-response
relationship in the human studies, and the negative laboratory studies.
15) If power-frequency fields don't explain the positive residential and
occupations studies, what could?
There are basically three factors that can result in false associations in
epidemiological studies. These are:
a) Inadequate dose assessment - if power-frequency fields are associated
with cancer, we do not know what aspect of the field is involved. At a
minimum, risk could be related to the peak field, the average field, of the
rate of change of the field. If we don't know who is really exposed, and who
is not, we will usually (but now always) underestimate the true risk.
b) Confounders - power lines (or electrical occupations) might be associated
with a cancer risk other than magnetic fields. Many confounders of the
powerline studies have been suggested: PCBs, herbicides, traffic density,
socioeconomic class. The first two are unlikely. PCB leakage is rare, and
PCB exposure has been linked to lymphomas, not leukemia or brain cancer.
Herbicide spraying would not effect distribution systems in urban areas
(where 3 of 4 positive childhood cancer studies have been done). Traffic
density may be a real confounder (see ref. 28). Socioeconomic class may be
an issue in both the residential and occupational studies, as socioeconomic
class is clearly associate with cancer risk, and "exposed" and "unexposed"
groups in many studies are of different socioeconomic classes (see ref. 29
for a discussion of some of these issues)
c) Publication bias - it is a known that positive studies are more likely to
be published than negative studies. This can severely bias meta-analysis
studies such as those discussed in Q10 and Q11. Such publication bias will
increase apparent risks. This is a bigger potential problem for the
occupational studies than the residential ones. It is also a clear problem
for laboratory studies -- it is much easier to publish studies that report
effects than studies that report no effects (such is human nature!).
16) What is the strongest evidence for and against a connection between
power-frequency fields and cancer?
The best evidence for a connection between cancer and power-frequency fields
a) The four epidemiological studies that show a correlation between
childhood cancer and proximity to high-current wiring (refs 1-3 plus the
Fleychting & Ahlbom study described in Q13).
b) The epidemiological studies that show a significant correlation between
work in electrical occupations and cancer, particularly leukemia and brain
cancer (refs 8-10).
c) The lab studies that how that power-frequency fields do produce
bioeffects. The most interesting of the lab studies are probably the ones
showing increased transcription of oncogenes at fields of 1-5 Gauss (100 -
500 microT) (see ref. 17 and 18).
d) The one laboratory study that provides evidence that power-frequency
magnetic fields can promote chemically-induced breast cancer (ref 32).
The best evidence that there is not a connection between cancer and power-
frequency fields is probably:
a) Application of the Hill criteria (Q14) to the entire body of
epidemiological and laboratory studies (refs 24 and 27)
b) The fact that all studies of genotoxicity, and all but one study of
promotion have been negative (Q12).
c) Adair's (ref. 25) biophysical analysis that indicates that "any biological
effects of weak [less than 500 mG, 50 microT] ELF fields on the cellular
level must be found outside of the scope of conventional physics"
d) Jackson's (ref. 26) epidemiological analysis that shows that childhood and
adult leukemia rates in the US have been stable over a period of time when
per capita power consumption in the US has risen by a factor of five.
17) What studies are needed to resolve the cancer-EMF issue?
In the epidemiological area, more of the same types of studies are unlikely
to resolve anything. Studies showing a dose-response relationship between
measured fields and cancer incidence rates would clearly affect thinking, as
would studies identifying confounders in the residential and occupational
In the laboratory area, more genotoxicity and promotion studies may not be
very useful. Exceptions might be in the area of cell transformation, and
promotion of chemically-induced breast cancer. Long-term rodent exposure
studies (the standard test for carcinogenicity) would have a major impact if
they were positive, but if they were negative it wouldn't change very many
minds. Further studies of some of the known bioeffects would be useful, but
only if they identified mechanisms or if they established the conditions
under which the effects occur (e.g., thresholds, dose-response relationships,
frequency-dependence, optimal wave-forms).
18) What are some good overview articles?
A good review of the area was published by Oak Ridge Associated Universities
(ref 40). It is available from National Technical Information Service (ARAU
92/F-8) and the US Government Printing Office (029-000-00443-9). If you're
in the U.K., the National Radiation Protection Board has a good review (ref
39). Two other good review are Theriault (ref. 24) and Bates (ref. 27).
19) Are there exposure standards for power-frequency fields?
Yes, a number of governmental and professional organizations have developed
exposure standards. These standards are based on keeping the body currents
induced by power-frequency EM fields to a level below the naturally occurring
fields (see Q7). The most generally relevant are:
- Guidance as to restriction on exposures to time varying EM fields and the
1988 recommendations on the International Non-Ionizing Radiation Committee,
National Radiation Protection Board, Chilton, 1989.
50/60 Hz E-field: ~10 kV/m (freq. dependent)
50/60 Hz H-field: 1630 A/m, 2 mT (20 G)
- Sub-radiofrequency (30 KHz and below) magnetic fields, In: Documentation of
the threshold limit values, American Committee of Government and Industrial
Hygienists, pp. 55-64,1992.
At 60 Hz: 1 mT (10 G); 0.1 mT (1 G) for pacemaker wearers
- HP Jammet et al: Interim guidelines on limits of exposure to 50/60 Hz
electric and magnetic fields. Health Physics 58:113-122, 1990.
24 hr general public: 0.1 mT = 1 G
Short-term general public: 1 mT = 10 G
Occupational continuous: 0.5 mT = 5 G
Occupational short-term: 5 mT = 50 G
24 hr general public: 5 kV/m
Short-term general public: 10 kV/m
Occupational continuous: 10 kV/m
Occupational short-term: 30 kV/m
1) N Wertheimer & E Leeper: Electrical wiring configurations and childhood
cancer. Amer J Epidemiol 109:273-284, 1979.
2) DA Savitz et al: Case-control study of childhood cancer and exposure to 60-
Hz magnetic fields. Amer J Epidemiol 128:21-38, 1988.
3) SJ London et al: Exposure to residential electric and magnetic fields and
risk of childhood leukemia. Amer J Epidemiol 134:923-937, 1991.
4) MP Coleman et al: Leukemia and residence near electricity transmission
equipment: a case-control study. Br J Cancer 60:793-798, 1989.
5) ME McDowall: Mortality of persons resident in the vicinity of electrical
transmission facilities. Br J Cancer 53:271-279, 1986.
6) A Myers et al: Childhood cancer and overhead powerlines: a case-control
study. Brit J Cancer 62:1008-1014, 1990.
7) G.B. Hutchison: Cancer and exposure to electric power. Health Environ
Digest 6:1-4, 1992.
8) M Coleman & V Beral: A review of epidemiological studies of the health
effects of living near or working with electrical generation and transmission
equipment. Int J Epidemiol 17:1-13, 1988.
9) JR Jauchem & JH Merritt: The epidemiology of exposure to EM fields: an
overview of the recent literature. J Clin Epidemiol 44:895-906, 1991.
10) DA Savitz & EE Calle: Leukemia and occupational exposure to EM fields:
Review of epidemiological studies. J Occup Med 29:47-51, 1987.
11) GK Livingston et al: Reproductive integrity of mammalian cells exposed to
power frequency EM fields. Environ Molec Mutat 17:49-58, 1991.
12) M Rosenthal & G Obe: Effects of 50-Hertz EM fields on proliferation and
on chromosomal aberrations in human peripheral lymphocytes untreated and
pretreated with chemical mutagens. Mutat Res 210:329-335, 1989.
13) J. Nafziger et al: DNA mutations and 50 Hz EM fields. Bioelec Bioenerg
14) A. Rannug et al: A study on skin tumor formation in mice with 50 Hz
magnetic field exposure. Carcinogenesis 14:573-578, 1993.
15) R. Zwingelberg et al: Exposure of rats of a 50-Hz, 30-mT magnetic field
influences neither the frequencies of sister-chromatid exchanges nor
proliferation characteristics of cultured peripheral lymphocytes. Mutat Res
16) TS Tenforde: Biological interactions and potential health effects of
extremely-low-frequency magnetic fields from power lines and other common
sources. Ann Rev Publ Health 13:173-196, 1992.
17) R Goodman & A Shirley-Henderson: Transcription and translation in cells
exposed to extremely low frequency EM fields. Bioelec Bioenerg 25:335-355,
18) RB Goldberg & WA Creasey: A review of cancer induction by extremely low
frequency EM fields. Is there a plausible mechanism? Medical Hypoth 35:265-
19) A Rannug et al: Rat liver foci study on coexposure with 50 Hz magnetic
fields and known carcinogens. Bioelectromag 14:17-27, 1993.
20) MA Stuchly et al: Modification of tumor promotion in the mouse skin by
exposure to an alternating magnetic field. Cancer Letters 65:1-7, 1992.
21) JRN McLean et al: Cancer promotion in a mouse-skin model by a 60-Hz
magnetic field: II. Tumor development and immune response. Bioelectromag
22) S Baumann et al: Lack of effects from 2000-Hz magnetic fields on mammary
adenocarcinoma and reproductive hormones in rats. Bioelectromag 10:329-333,
23) AB Hill: The environment and disease: Association or causation? Proc
Royal Soc Med 58:295-300, 1965.
24) G Theriault: Cancer risks due to exposure to electromagnetic fields. Rec.
Results Cancer Res. 120:166-180; 1990.
25) RK Adair: Constraints on biological effects of weak extremely-low-
frequency electromagnetic fields, Phys Rev A 43:1039-1048, 1991.
26) J.D. Jackson: Are the stray 60-Hz electromagnetic fields associated with
the distribution and use of electric power a significant cause of cancer?
Proc Nat Acad Sci USA 89:3508-3510, 1992.
27) MN Bates: Extremely low frequency electromagnetic fields and cancer: the
epidemiologic evidence, Environ Health Perspec 95:147-156, 1991.
28) DA Savitz & L Feingold: Association of childhood leukemia with
residential traffic density. Scan J Work Environ Health 15:360-363, 1989.
29) JM Peters et al: Exposure to residential electric and magnetic fields
and risk of childhood leukemia. Rad Res 133:131-132, 1993.
30) JD Sahl et al: Cohort and nested case-control studies of hematopoietic
cancers and brain cancer among electric utility workers. Epidemiology 4:104-
31) J McCann et al: A critical review of the genotoxic potential of electric
and magnetic fields. Mut Res 297:61-95, 1993.
32) W Loscher et al: Tumor promotion in a breast cancer model by exposure to
a weak alternating magnetic field. Cancer Letters 71:75-81, 1993.
33) AR Liboff et al: Time-varying magnetic fields: Effects on DNA synthesis.
Science 223:818-820, 1984.
34) I Penn: Why do immunosuppressed patients develop cancer? Crit Rev
Oncogenesis 1:27-52, 1989.
35) GR Krueger: Abnormal variation of the immune system as related to
cancer. Cancer Growth Prog 4:139-161, 1989.
36) P Guenel et al: Incidence of cancer in persons with occupational
exposure to electromagnetic fields in Denmark. Brit J Indus Med 50:758-764,
37) PJ Verkasalo et al: Risk of cancer in Finnish children living close to
power lines. Brit Med J (BMJ) 307:895-899, 1993.
38) JH Olsen et al: Residence near high voltage facilities and risk of
cancer in children. Brit Med J (BMJ) 307:891-895, 1993.
39) R Doll et al, Electromagnetic Fields and the Risk of Cancer, National
Radiation Protection Board, Chilton, 1992.
40) JG Davis et al: Health Effects of Low-Frequency Electric and Magnetic
Fields. Oak Ridge Associated Universities, 1992.
41) J Walleczek: Electromagnetic field effects on cells of the immune
system: the role of calcium signaling. FASEB Journal 6:3177-3185, 1992.
42) RG Stevens et al: Electric power, pineal function, and the risk of
breast cancer. FASEB Journal 6:853-860, 1992.
43) RJ Reiter & BA Richardson: Magnetic field effects on pineal indoleamine
metabolism and possible biological consequences. FASEB Journal 6:2283-2287,
44) GH Schreiber et al: Cancer mortality and residence near electricity
transmission equipment: A retrospective cohort study. Int J Epidem 22:9-15,
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