Table 6-4. Clinical pharmacokinetics and dosages of ADH and its congeners and an ADH antag

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Table 6-4. Clinical pharmacokinetics and dosages of ADH and its congeners and an ADH antagonist, demeclocyline. Presc Cat contains the controlled drug and FDA pregnancy safety category codes To calculate dose for a significantly over/underweight patient: __________________________________________________________________________ Drug Recommended Time to Available Dose Dosing onset Duration Presc as Interval (hrs) (hrs) Cat _______________(mg)__(hrs)________________________________________________ ADH AGONISTS (Not for oral use) Antidiuretic hormone Rx;D Posterior pituitary (a partially purified animal preparation) Nasal 40mg (45 units) 6-8 8-12 Vasopressin (8-arginine-vasopressin) Pitressin Synthetic: 20 pressor units/mL in 0.5 or 1 mL ampules IM or SC 5-10 units 3-4 Vasopressin tannate Pitressin tannate in oil: 5 U/mL in 1 mL ampules IM 0.3-1 mL 24-96 (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Interval(h) Onset(h) Dur(h) Cat 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Desmopressin DDAVP: 0.1 mg/mL nasal solution; Nasal 0.1-0.4 mL QD as a single dose or 2-3 divided doses Stimate: 40 ug/10 mL for injection) SC or IV 0.5-1.0 mL BID 8-20 Rx;B Lypressin Diapid: nasal spray 0.185 mg/mL 1-2 sprays 6 0.5-1 3-8 Rx;C ------------------------------------ ADH ANTAGONIST (oral use only) Demeclocycline Declomycin: 150 mg tabs and caps 150 6 12-24 Rx;X ========================================================================= (Home key to return to top of table)

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