Table 6-3. Clinical pharmacokinetics and dosages of the non-thiazide diuretics. Presc Cat

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Table 6-3. Clinical pharmacokinetics and dosages of the non-thiazide diuretics. Presc Cat contains the controlled drug (Rx) and FDA pregnancy safety category codes (B,C) To calculate dose for an over/underweight patient: _________________________________________________________________________ Drug Recommended Time to Duration Available Dose Dosing onset (half-life) Presc as Interval (hrs) (hrs) Cat Notes _______________(mg)__(hrs)_______________________________________________ LOOP DIURETICS Bumetanide Bumex: 0.5,1 mg tabs; 0.5 mg/2 mL amp for IV or IM injection 0.5-2 12-24 0.1-1 2-6 Rx;(C) 1 Ethacrynic acid Edecrin: 25,50 mg tabs; 50 mg powder/vial for IV (only) injection 50-100 24 0.1-0.5 2-8 Rx;(C) 1 Furosemide generic, Lasix: 20,40,80 mg tabs; 10 mg/mL oral suspension; 10 mg/mL for IM or IV injection 20-80 12-24 0.1-1 2-8 Rx;(C) 1 (End key for footnotes, PgDn for more drugs) POTASSIUM-SPARING DIURETICS 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Interval Onset(h) Dur(h) Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Amiloride Midamor: 5 mg tabs 5-20 24 2 24 Rx;B Spironolactone generic, Aldactone: 25,50,100 mg tabs 25-200 24 24-48 48-72 Rx;(C) Triamterene generic, Dyrenium: 50,100 mg tabs 100-150 12 2 12-16 Rx;(C) (PgDn key for more drugs) CARBONIC ANHYDRASE INHIBITORS 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Interval Onset(h) Dur(h) Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Acetazolamide generic, Diamox: 125,250 mg tabs; 500 mg sustained release caps; 500 mg/vial for injection 250-500 12-24 2-3 Rx;(C) 2 Dichlorphenamide Daranide: 50 mg tabs 25-50 8-24 1-2 6-12 Rx;(C) 3,4 Methazolamide Neptazane: 50 mg tabs 50-100 8-12 2-3 10-18 Rx;(C) 4 (End key for footnotes, PgDn key for more drugs) OSMOTIC DIURETICS 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Interval Onset(h) Dur(h) Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 see manufacturer's recommendations for the specific indication Mannitol (IV use only) Rx;(C) generic, Osmitrol: available in 5, 10, 15, 20, and 25% solutions Isosorbide (Oral use only) Rx;(B) Ismotic: available as 45% (0.45g/mL) solution Glycerine (Oral use only) Rx;C Glyrol: 75% (0.94g/mL) solution Osmolglyn: 50% (0.6g/mL) solution Urea (IV use only) Rx;C Ureaphil: 40 g/150 mL solution ========================================================================= (PgDn key for footnotes) FOOTNOTES: 1. Onset of action within minutes after injection; 1 hour after oral ad- ministration. 2. Given daily in the dosages listed for the treatment of glaucoma and epilepsy; 2 days out of every 3 at 1/2 to 1/3 the listed dosage in edema due to congestive failure. 3. Loading dose 4 times greater suggested until desired effect is achieved. 4. Indicated for glaucoma; not recommended for use as a diuretic. (Home key to return to top of file)

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