Table 5-3. Vasodilators used in chronic hypertension. SR: slow release formulation. Admini

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Table 5-3. Vasodilators used in chronic hypertension. SR: slow release formulation. Administration is by the oral route unless noted. Presc Cat contains the controlled drug and FDA pregnancy safety category codes To calculate dose for over/underweight patients: ___________________________________________________________________________ Drug Recommended (Available as) Dose Dosing Onset Duration Pres Interval Cat Notes __________________mg____hours_____(min)____(hours)________________________ Hydralazine (generic, Apresoline: 10,25,50,100 mg tabs; 20 mg/mL injection) Oral 10-50 6 -- 4-8 Rx;C 1 Parenteral: 20-40 IV or IM. Repeat as required. Minoxidil (Loniten: 2.5, 10 mg tabs) 5-50 24 30 75 Rx;C Diltiazem (Cardizem: 30,60,90,120 mg tabs) 30-90 6-8 30 3-4 Rx;C 2 Nifedipine (Adalat,Procardia: 10,20 mg caps) 2 (oral) 10-30 6-8 hr 20 4 Rx;C (sublingual) 10 3 4 Rx;C Verapamil (Calan, Isoptin: 80,120 mg tabs; CalanSR 240 mg tabs) 80-120 6-8 hr 30 6 Rx;C CalanSR 240-480 24 hr ==========================================================(PgDn for notes) NOTES: 1. Half-life is acetylator phenotype-dependent and longer in slow acetylators. 2. Unlabeled use at time of writing. (Home key to return to top of table)

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