Table 5-2. Sympathoplegic drugs used in hypertension. For beta-blockers, see Table 5-1. Ro

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Table 5-2. Sympathoplegic drugs used in hypertension. For beta-blockers, see Table 5-1. Route of administration is oral unless noted. Presc Cat contains the controlled drug and FDA pregnancy safety category codes Calculate dose for over/underweight patients: ___________________________________________________________________________ Drug Recommended (Available as) Dose Dosing Onset Duration Pres Interval Cat Notes __________________mg____hours______________________________________________ CENTRALLY-ACTING DRUGS: Clonidine (generic, Catapres: 0.1,0.2,0.3 mg tabs; Catapres-TTS transdermal in sizes that release 0.1,0.2,or 0.3 mg/24hr) 0.1-0.4 12 30-60min 12-24 Rx;C Transdermal 1-2 systems/week 1-3 days 5-8 days Guanabenz (Wytensin: 4-8 mg tabs) 8-32 12 2-5 hr 6-8 hr Rx;C Guanfacine (Tenex: 1 mg tabs) 1-3 24 12-24 hr Rx;B (PgDn for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset(min) Dur Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Methyldopa (generic, Aldomet: 125,250,500 mg tabs; 250 mg/5 mL oral suspension) 500-3000 12 12-48hr 24 hr Rx;B Parenteral (Methyldopate HCl: 250 mg/5 mL injection) 250-1000 6 IV over 30-60 min -------------------------------------------- POSTGANGLIONIC SYMPATHETIC NERVE TERMINAL BLOCKERS: Guanadrel (Hylorel: 10,25 mg tabs) 5-30 8-12 na 10-12 hr Rx;B Guanethidine (Ismelin: 10,25 mg tabs) 10-50 24 6-24hr 5-7 days Rx;B Reserpine (generic, Serpasil: 0.1,0.25,1.0 mg tabs) 1 0.1-0.25 24 12-48 weeks Rx;D 50-100hr -------------------------------------------- NOTES: 1. Analogs of reserpine include deserpine, rescinnamine, alseroxylon. (PgDn for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset(min) Dur Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 ALPHA ADRENOCEPTOR BLOCKERS: Phenoxybenzamine (Dibenzyline: 10 mg caps) 2 20-40 8-12 0.5-5hr 24-48 Rx;C Phentolamine (Regitine: 5 mg/mL injection) 3 (IM or IV) 5mg 15-30 min 1-10min 20-40min Rx;B Prazosin (Minipress: 1,2,5 mg caps) 3-15 8-12 30-180min 10 hr Rx;B Terazosin (Hytrin: 1, 2, 5 mg tabs) 3-15 12-24 120-180 12-24 Rx;C ------------------------------------------------ GANGLION BLOCKERS: Mecamylamine (Inversine: 2.5 mg tabs) 4 2.5-8 8-12 0.5-2hr 6-12 Rx;B Trimethaphan: see Table 5-5 =========================================================================== Notes: 2. Used only in the management of pheochromocytoma. 3. Used in the diagnosis and management of pheochromocytoma, and to reduce tissue ischemia following infiltration of norepinephrine. 4. Obsolete. (Home to return to top of file)

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