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F1 KEY = HELP; ESC = MAIN SCREEN; HOME = TOP OF FILE; PgDn = MORE TEXT LEFT ARROW = LAST FILE; RIGHT ARROW or ENTER = JUMP TO HIGHLIGHT FILE Table 4-1. Positive inotropic drugs used in congestive heart failure and related agents. See for information on thiazides and other diuretics; and for information on vasodilators. To calculate dose for an over/underweight patient: Presc Cat contains the controlled drug and FDA pregnancy safety category codes __________________________________________________________________________ Drug Recommended (Available as) Dose Dosing Presc Interval Onset Half-life Cat Notes ______________________(mg)___(hrs)__(hrs)____(hrs)_____________________ DIGITALIS PREPARATIONS Digitalis leaf (generic, various: 100 mg tabs, caps) (oral) 100 q24h 6-12 168 Rx Digitoxin (generic, various: 0.05,0.1,0.15,0.2 tabs; 0.2 mg/mL injection) (maintenance) 0.1 q24h 6-12 168 Rx;C 1 (loading) 1.2-1.6 give as three divided doses 1 over 24 hours (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset t Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Digoxin (generic, Lanoxin: 0.125,0.25,0.5 tabs; 2 0.05 mg/mL elixir; 0.1,0.25 mg/mL injection) (oral maintenance) 0.1-0.25 q24h .5-2 40 Rx;C (oral loading) 0.5-0.75 initially, 0.25-0.5 after 8-12 hours (IV loading) 0.4-0.6 initially, 0.2-0.4 after 6-8 hours if needed 3 Deslanoside (Cedilanid-D: 0.2 mg/mL injection) (IV or IM) 1.6 q24h Rx 3 Gitalin (Gitaligin: 0.5 mg tabs) 0.25-1.0 q24h 4-8 40 Rx;C DIGITALIS ANTIBODIES Fab fragments (ovine, digoxin specific [Digibind]) see package instructions 4 (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset t Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 SYMPATHOMIMETICS (listing limited to those used in congestive heart fail- ure) Dobutamine (Dobutrex: 250 mg/20 mL injection) 2.5-10mcg/kg/min 1-2min 2 min Rx;C Dopamine (generic,Intropin: 40,80,160 mg/mL injection; 80,160 mg/100 mL in 5%D/W injection) 5-50mcg/kg/min 1-2min 1-3min Rx;C 5 OTHER POSITIVE INOTROPIC DRUGS Amrinone (Inocor: 5 mg/mL injection) 0.75mg/kg 30min 3.6-5.8 Rx;C 5 ========================================================================== NOTES: 1. Oral or IV dose. 2. Half-life prolonged in renal disease. Reduce dosage in the elderly when creatinine clearance falls below 50 mL/min. 3. For rapid parenteral digitalization. Start oral preparation (eg, maintenance dose of digoxin) concurrently. 4. For the treatment of severe digitalis intoxication. 5. Not intended for use, or safety not established, in children under 12. (Home to return to top of file)

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