Table 3-3. Properties of the Group II, III, and IV antiarrhythmic drugs. Presc Cat contain

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Table 3-3. Properties of the Group II, III, and IV antiarrhythmic drugs. Presc Cat contains the controlled drug and FDA pregnancy safety prescribing category codes Calculate dose for over/underweight patients: _________________________________________________________________________ Drug Recommended Half- Plasma level (Available Dose life Thera- Toxic Presc as) (mg) peutic Route Cat Notes ________________________________________(mg/L)___________________________ GROUP II: Acebutalol 3-4 0.2-2 Rx;B (Sectral: 200,400 mg caps) 200-600 BID Oral Esmolol minutes Rx (Brevibloc: 250 mg/mL for IV infusion) 50-200 ug/kg.min Propranolol 3-5h 0.05-0.1 Rx;C (generic, Inderal: 10,20,40,60,80,90 mg tabs;80,120,160 mg SR caps; 1 mg/mL injection) 1 10-30 Q6-8hr Oral 1-3 IV 2 (PgDn to scroll) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose t Rx-Level-Tx Route Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 GROUP III: Bretylium 5-10 0.5-1.5 Rx;(C) (Bretylol: 50 mg/mL injection) 5 mg/Kg IV Bolus Rx 1-2 mg/min IV Infusion ______________________________________________________________________ GROUP IV: Verapamil 3-7 0.08-0.3 >0.3 Rx;B Calan, Isoptin: 80,120 mg tabs;240 mg SR tabs; 5 mg/2 mL injection) 5-10mg (0.075-0.15mg/kg) IV First dose, give slowly. 10mg IV If first dose not effective Diltiazem (Cardizem: 30,60,90,120 mg tabs) Unlabeled use; see ========================================================================== Footnotes: 1. SR: sustained release forms. 2. For life-threatening arrhythmias only, give no faster than 1mg/min, may be repeated once. (Home key to return to top of table)

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