Table 3-1. Pharmacokinetic properties and doses of Group IA antiarrhythmic drugs. Presc Ca

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Table 3-1. Pharmacokinetic properties and doses of Group IA antiarrhythmic drugs. Presc Cat contains the controlled drug and FDA pregnancy safety prescribing category codes Calculate dose for significantly over/underweight patient: _________________________________________________________________________ Drug Recommended Half- Plasma level (Available Dose life Thera- Toxic Presc as) (mg) peutic Route Cat Notes ________________________________________(mg/L)___________________________ GROUP IA: Disopyramide (Toxicity: ) (generic,Norpace:100,150 mg caps) 100-200 QID 4-10 2-8 >9 Oral Rx;C 1 controlled release: 100, 150 mg caps 200-400 BID Oral Procainamide (Toxicity: ) (generic, Pronestyl: 250,375,500 mg tabs, caps, 100,500 mg/mL injection) 500-1000 Q3-4hr 2.5-4.5 4-8 >16 Oral Rx;C (PgDn key for scroll) _________________________________________________________________________ Drug Recommended Half- Plasma level (Available Dose life Thera- Toxic Presc as) (mg) peutic Route Cat Notes ________________________________________(mg/L)___________________________ Procainamide, sustained release (generic, Procan-SR: 250,500,750,1000 mg tabs) 750-1500 QID 2 Quinidine (Toxicity: ) sulfate 6-8 3-6 >8 Rx;C (generic, 83% quinidine base: 100,200,300 mg tabs,caps; 200 mg/mL injection) 200 once Oral or IM Test dose 200-300 Q6-8hr Oral Maintenance 300-600 IV Inject diluted solution slowly sulfate (Quinidex: 300 mg SR tabs) 3 300-600 Q8-12hr (PgDn key for scroll) gluconate (62% quinidine base) (generic, Duraquin: 324,330 mg SR tabs; 80 mg/mL injection) 330-660 Q8-12hr Oral sustained release 300-600 IV Inject diluted solution slowly polygalacturonate (60% quinidine base) (Cardioquin: 275 mg tabs) 275-550 Q8-12hr Oral ========================================================================= Footnotes: 1. CR caps: controlled release capsules. 2. Sustained release procainamide is preferred by many clinicians because the half-life of regular procainamide is very short. 3. SR: sustained release forms.

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