Table 2-1. Clinical pharmacokinetics of nitrates and nitrites in the treatment of angina p

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Table 2-1. Clinical pharmacokinetics of nitrates and nitrites in the treatment of angina pectoris. Other vasodilators: . Presc Cat contains the controlled drug codes and the FDA pregnancy safety category codes Calculate dose for significantly over/underweight patient: Toxicity: __________________________________________________________________________ Drug Recommended Onset Duration Presc (Available Dose (min) Cat Notes ____as)__________________________________________________________________ Amyl nitrite (generic,Aspirols, for inhalation 0.18-0.30 ml) 2-6 inhalations 0.5 3-5 min Rx;C Crush vial in fabric, use 2-6 inhalations. Erythrityl tetranitrate (Cardilate:5,10 mg sublingual tabs;10 mg chewable) sublingual 5-10 mg (PRN) 5 3 hr Rx;C Do not swallow. chewable 10-30 mg TID 30 6 hr Rx;C Swallow, prophylactic. (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset(min) Dur Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Isosorbide dinitrate (generic,Isordil,Sorbitrate) sublingual (2.5,5,10 mg tabs) 2.5-10 mg prn 2-5 0.5-2 hr Rx;C Do not swallow. oral (5,10,20,30,40 mg tabs); chewable (5,10 mg tabs) 5-20 mg Q4-6hr 20-40 4-6 hr Rx;C Prophylactic use oral,sustained release (40 mg tabs, caps) 40 mg Q6-12hr "slow" 8-10 hr Rx;C Prophylactic use Nitroglycerine intravenous (Nitroglycerin IV, Nitro IV, etc: 0.5,0.8,5 mg/mL) 5-100 mcg/min 1 3-5 min Rx;C Used in unstable angina. sublingual tablets (generic, Nitrobid, Nitrostat, etc: 0.15,0.3,0.4,0.6 mg tabs) 0.15-0.6 mg prn 1-3 15-60 min Rx;C Abort acute attack (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset(min) Dur Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Nitroglycerine, cont. sublingual aerosol (Nitrolingual: 0.4 mg/metered dose) 0.4 mg prn 1-3 15-60 min Rx;C Abort acute attack. Spray under tongue- do not inhale. buccal (Nitrogard: 1,2,3 mg) 1-3 mg Q3-5hr 3 3-5 hr Rx;C Prophylactic use. Place under upper lip or in buccal pouch oral (generic: 2.5,6.5,9 mg SR tabs, caps) 2.5-9 mg Q8hr 30-60 4-6 hr Rx;C Prophylactic use topical ointment (generic, Nitrong, etc: 20 mg/mL) 7.5-30 mg (1-5 cm) TID 20-60 2-8 hr Rx;C Prophylactic use transdermal (Nitrodisc-5,7.5,10; Nitro-Dur 2.5,5,7.5,10,15; Transderm-Nitro 2.5,5,10,15; NTS-5,15) Prophylactic use but 12.5-187.5 mg/patch duration not 24 hr as (2.5-15 mg released) QD 40-60 4-8 hr Rx;C claimed. (PgDn key for more drugs) 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Drug Dose Onset(min) Dur Cat Notes 컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴컴 Pentaerytritol tetranitrate (generic,PETN,Peritrate) oral (10,20,40,80 mg tabs) 10-20 mg QID 30 4-5 hr Rx;C Prophylactic use oral, sustained release (30,45,60,80 mg SR caps) 30-80 mg BID 30 4-12 hr Rx;C Prophylactic use ========================================================================== Drug Handbook: , Antianginal Drugs (Home to return to top of file)

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