III. OTHER POSITIVE INOTROPIC DRUGS Amrinone, dobutamine, and dopamine are +quot;non-digit

Master Index Current Directory Index Go to SkepticTank Go to Human Rights activist Keith Henson Go to Scientology cult

Skeptic Tank!

III. OTHER POSITIVE INOTROPIC DRUGS Amrinone, dobutamine, and dopamine are "non-digitalis positive in- otropic drugs" currently approved for short-term use in congestive heart failure. Pharmacokinetics (see also ). * Absorption: These drugs are approved for parenteral use only. * Elimination: Amrinone is eliminated by both hepatic and renal mechan- isms. Dobutamine and dopamine are both catecholamines and are metabol- ized by catechol-O-methyltransferase (COMT). Dopamine is also metabol- ized by monoamine oxidase (MAO). Other Indications These digitalis substitutes are not approved for any other uses and unlabelled uses are insignificant at present. Contraindications and Warnings * Obstructive cardiomyopathy * Digitalis toxicity * Ventricular arrhythmias * Sympathomimetic toxicity, eg, pheochromocytoma (PgDn key for more text) Adverse Reactions and Toxicities * Amrinone: - Hematologic: thrombocytopenia. - GI: nausea, vomiting, abdominal pain, hepatotoxicity. - CV: arrhythmias, hypotension. - Treatment: Monitor platelet count; reduce dosage or stop drug if platelet count drops below 150000/mm3. * Dobutamine: - CV: hypotension, tachycardia, angina, arrhythmia - Miscellaneous: headache, gi distress, shortness of breath. * Dopamine: - CV: arrhythmias, tachycardia, angina, hypertension - Miscellaneous: nausea and vomiting, headache, dyspnea Interactions * MAO inhibitors: potentiate dopamine and to a lesser extent, dobutamine. * Halogenated hydrocarbon anesthetics: sensitize the myocardium to the arrhythmogenic actions of the positive inotropic agents. (Home key to return to top of file)


E-Mail Fredric L. Rice / The Skeptic Tank